Cholestatic Liver Disease

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The term "cholestasis" literally means "the cessation of bile. If the flow is disturbed bile in your body rises anicteric cholestasis in the body. Middle-aged women aged over 40 are suffering as a rule the type of chronic liver disease cholestatic. This type of disease is called "primary biliary cirrhosis."

Diagnosis

About 90 percent of patients diagnosed with primary biliary cirrhosis are women aged over 40 years. Women living inNorthern Europe are generally more susceptible to this disease than women in other parts of the world. Women in Japan have the lowest rate of diagnosed cases of this disease.

The diagnosis of cholestatic liver diseases based on a combination of many observations and tests performed. Some of these factors are the results of cholestatic liver enzymes, positive anti-mitochondrial antibodies, and characteristic liver biopsy. The most common laboratory is the identification of serum --alkaline phosphates of liver origin. The presence of anti-mitochondrial antibody is the most characteristic laboratory finding in cholestatic liver disease. About 95 percent of all those who suffer from the disease the test is positive for anti-mitochondrial antibodies.

Signs and symptoms

Fatigue is the most common symptom of this disease. Seventy Eighty percent of all patients with this disease, this symptom occurs. However, fatigue is not usually an indication ofseverity of this disease. As the disease progresses, you may experience other symptoms such as high blood pressure. As the disease progresses even more is the ability to record, fat-soluble vitamins, has continued to decline. As the disease progresses, autoimmune diseases are beginning to develop. For example, a patient with this disease begins to develop an autoimmune disease of the thyroid, and inflammatory bowel disease, once the disorder is left to progress.

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